One of the main challenges in the development of effective pro-cognitive treatments is the ability to accurately assess the level of a patient’s cognitive dysfunction or any pro-cognitive changes due to therapeutic intervention.

Thanks to the latest electronic sensor design, advanced signal processing, and web-based data management, ERP and qEEG testing can now provide objective, sensitive and reliable physiological measures of cognitive function that can be practically applied throughout the drug development process.

COGNISION® makes implementation of ERP and qEEG testing in clinical trials practical and scalable through a fully integrated hardware/software platform.

Advanced Features
  • Wireless, battery-powered system for use in an office environment
  • Subject-friendly headset fits a large range of head sizes
  • Calibrated insert earphones ensure consistent auditory stimuli
  • Active electrodes provide high SNR and fewer artifacts
  • Integrated action buttons for subject responses
  • Convenient Hydro-Dot® Biosensors are easy to apply and deliver very low skin contact impedance
Technical Specifications
  • Channels: Fz, Cz, Pz, F3, P3, F4, P4, M1, M2
  • Sampling Rate: 250 samples/sec
  • Band Pass: 3-70 Hz
  • CMRR (50/60 Hz): >130 dB
  • Noise (RTI): <1 μVRMS
  • Power: Li-ion Battery
  • Data Communication: Bluetooth

How COGNISION® Helps Clinical Trials

Complete Flexibility in Test Design

COGNISION® allows for testing protocols tailored to the investigational drug mechanism of action and/or cognitive deficits specific to the target population.

 

Easy and Fast Set Up

COGNISION® is practical to operate even for users with minimal electrophysiology training, thus providing maximum flexibility in clinical study sites selection.

 

Consistent Results Across Clinical Study Sites

COGNISION® uses advanced active electrodes that produce high quality data in any testing environment, ensuring consistent data quality across clinical study sites and reducing inter-site variability.

 

Writes Clinical Protocols in Real Time

COGNISION® automatically loads new protocols in real time, can quickly run additional protocols within the same system and has strong test and re-test reliability.

 

Results Are Available Real Time

COGNISION® provides automated data analysis that allows for rapid evaluation of treatment effects when needed, such as in adaptive studies.

 

Available For Global Clinical Trial Use

COGNISION® can be used at any number of test sites and has facilitated large-scale global clinical trials as far away as Australia, Tasmania and New Zealand.

 

Centralized Storage of Data

COGNISION® uses cloud-based software for data sharing that provides authorized study personnel with centralized access to data and documents in multi-center studies.

Advantages of COGNISION® Biomarkers

  • Primary physiologic measure of the synchronous, large-scale synaptic activity underlying all brain functions
  • More proximal to disease pathology and pharmacological intervention than psychometric measures
  • Sensitive to many of the effects of psychotropic or acute-acting CNS compounds
  • Unaffected by habituation and can be measured repeatedly without learning effects
  • Sensitive measure of disease progression for monitoring chronic conditions
  • Translational measures with direct animal/human correlates

Complete Flexibility in Test Design

COGNISION® allows for testing protocols tailored to the investigational drug mechanism of action and/or cognitive deficits specific to the target population.

 

Easy and Fast Set Up

COGNISION® is practical to operate even for users with minimal electrophysiology training, thus providing maximum flexibility in clinical study sites selection.

 

Consistent Results Across Clinical Study Sites

COGNISION® uses advanced active electrodes that produce high quality data in any testing environment, ensuring consistent data quality across clinical study sites and reducing inter-site variability.

 

Writes Clinical Protocols in Real Time

COGNISION® automatically loads new protocols in real time, can quickly run additional protocols within the same system and has strong test and re-test reliability.

 

Results Are Available Real Time

COGNISION® provides automated data analysis that allows for rapid evaluation of treatment effects when needed, such as in adaptive studies.

 

Available For Global Clinical Trial Use

COGNISION® can be used at any number of test sites and has facilitated large-scale global clinical trials as far away as Australia, Tasmania and New Zealand.

 

Centralized Storage of Data

COGNISION® uses cloud-based software for data sharing that provides authorized study personnel with centralized access to data and documents in multi-center studies.